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The Time of Spontaneous Resolution of Monosymptomatic Nocturnal Enuresis (MNE) Is Familial

By U. Oguz, A. Aykac, E. Demirelli, E.B. Sancak, B. Resorlu, S. Sarikaya, E. Damar, O.F. Bozkurt, E. Ogreden, and O. Yalcin.

Urologia Internationalis, 30 January 2015, DOI: 10.1159/000370166, Article in Press

Editor’s comments:
It is a returning question from bedwetting children and their parents, if we are able to predict when they will become dry (spontaneously). We know by now that bedwetting is a hereditary condition, but it is unknown if the time to spontaneous resolution is also genetically predisposed. In this study, the authors give a first indication that it might be indeed.


To investigate whether or not the age of spontaneous resolution of monosymptomatic nocturnal enuresis (MNE) was familial.

A questionnaire was administered to more than 1,500 people, and 100 appropriate participants were identified from four referral hospitals. We included the participants who had MNE and whose parents also had MNE with spontaneous resolution. Then the association between the spontaneous resolution time of MNE in parents and that in their children was investigated.

The mean ages of spontaneous resolution were 10.7 (10-30 years), 9.4 (6-17 years) and 10.9 (6-18 years) in participants, their mothers and their fathers, respectively. According to the statistical analysis, there was a positive correlation between participants and both their mothers and fathers (p < 0.05). In addition, it was revealed that familial MNE history based on first- and second-degree relatives, in addition to their parents, was also associated with the increased spontaneous resolution age of MNE (p < 0.05). According to our results, gender and parents' education status were not statistically associated with the spontaneous resolution (p > 0.05).

As a conclusion, the age of spontaneous resolution of MNE is familial. Although the exact reasons of spontaneous resolution still remain a mystery; further genetic investigations may be able to resolve this mystery.


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Consensus Guidelines

Practical consensus guidelines for the management of enuresis. 
Evaluation and management of enuresis, a common condition, is not a priority in training programs for medical doctors (MDs), despite being a common condition.