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Efficacy of desmopressin and enuresis alarm as first and second line treatment for primary monosymptomatic nocturnal enuresis: prospective randomized crossover study.
By K.W. Kwak, Y.-S. Lee, K.H. Park, and M. Baek.
Journal of Urology, Volume 184, Issue 6, December 2010, Pages 2521-2526
Desmopressin and alarm treatment have a similar primary success rate and switching of treatment can be beneficial.This study has focused on the success rate of desmopressin and alarm as a primary treatment or a second line crossover treatment if the first treatment was unsuccessful. 104 children were included in the prospective study. Following the first line treatment 78% of the desmopressin group and 82% of the alarm treatment had a partial or full response. Following the second line crossover treatment, 71% of the alarm-desmopressin group and 68% of the desmopressin-alarm group achieved partial or full response . In addition, the authors have found that the relapse rate after desmopressin was higher than after the alarm treatment. The authors stated that switching to the alternative treatment was beneficial.